Officers responded to the King's Rest Motel, located at 8175 Monterey St., at around 10:30 p.m.
Police discovered several rifle rounds that had been fired through the front window of one of the rooms, police said.
Several of the occupants of the room fled after the shooting. Three of the occupants were found but there were other guests who had not been located as of this morning, police said.
No one was reported injured.
There appeared to have been two suspects who fled on foot and the weapon was not recovered, police said.
The suspects were described as men between the ages of 20 and 25, with medium to heavy builds, wearing dark clothing.
Anyone with information is asked to call (800) 782-7463.