The crash was reported at about 8:30 a.m. near the intersection of Kato Road and Benicia Street, Fremont police Detective Bill Veteran said.
The cement truck driver, whose name is not yet being released, was killed in the crash while the big-rig driver was hospitalized with injuries that are not considered life-threatening, Veteran said.
The investigation into the collision is expected to close Kato Road for several hours, and motorists are advised to avoid the area, according to police.
