The crash was reported at 7:59 p.m. on Park Presidio Boulevard near Fulton Street.
The motorcyclist, identified by the medical examiner's office as Rick Scheuer, was traveling south on Park Presidio Boulevard and was navigating a curve in the roadway when he hit the car next to him, police spokesman Officer Gordon Shyy said.
Scheuer, a San Francisco resident, was thrown from his motorcycle onto the pavement, and the car he had struck, a four-door sedan, ran over him, Shyy said.
Scheuer was taken to San Francisco General Hospital where he was pronounced dead.
The male driver of the sedan stopped at the scene, cooperated with investigators, and is not expected to face criminal charges in connection with the crash, Shyy said.