Police responded to the shooting at Club 101, located at 815 Francisco Blvd. West at about 12:45 a.m., according to San Rafael police Lt. Dan Fink.
Based on the initial police investigation, a physical altercation occurred amongst patrons inside the nightclub and spilled out into the club's parking lot, Fink said.
When police arrived at the nightclub, two victims were located with gunshot wounds. The victims were transported to Marin General Hospital with injuries not considered to be life threatening, Fink said.
Officers reported a large crowd of possibly more than 100 people in the club's parking lot.
Police located multiple firearms at the scene of the shooting and detained two people for unrelated violations, Fink said.
The shooting remains under investigation and police are speaking with witnesses.
Police had not made any arrests in connection to the shooting as of 6 a.m., according to Fink.