At about 9:45 a.m. Tuesday, officers responded to a report of a possible burglary at a home in the 2400 block of Eucalyptus Way, police said.
A passerby told police that at about 9:20 a.m., four men left the home with property, and fled in two cars, according to police.
Officers determined that the front door of the home had been forced open and the inside was ransacked, police said.
The suspects are described as men in their late teens or early 20s, last seen wearing dark clothing, police said.
Anyone with information about the burglary is asked to call San Bruno police at (650) 616-7100.