Dispatchers received a report of a person shot in front of a hotel in the 500 block of East 18th Street around 3:45 a.m., according to police.
Police said officers arrived on the scene to find the victim, a 38-year-old man, suffering from multiple gunshot wounds.
The officers and medical personnel performed life-saving measures on the man, but he was pronounced dead at the scene a short time later.
Police are investigating the shooting as a homicide.
No information about potential suspects was available.
Anyone with information about this case is encouraged to call Antioch police Detective Meads at (925) 779-6884.