Former Bay Area photographer Joseph Naso is charged with killing four women between 1977 and 1994. Their bodies were found along rural roads in Yuba, Marin, and Contra Costa counties.
The 79-year-old is representing himself. The accused "Alphabet Killer" is expected to give an opening statement to the jury Monday afternoon.
The trial could last until mid-November.
Naso could face the death penalty if convicted of the murders.
The name "Alphabet Killer" came because each of the victims had first and last names that start with the same letter.