The seven-alarm fire on Marigold Drive near Interstate Highway 80 was contained but about 50 residents in the area remained evacuated, Fairfield fire spokesman Bob Silva said.
The fire started in grass along Interstate Highway 80 at about 3:40 p.m. and quickly spread to homes along parallel Marigold Drive, according to fire officials.
A total of 15 homes were burned in the fire, five homes are uninhabitable and two are completely destroyed.
About 50 residents were evacuated in total along Marigold Drive, and North Texas Street was closed between Dickson Hill Road and Atlantic Avenue, Silva said.
An evacuation center has been established at Fairfield High School at 205 E. Atlantic Ave. where the Red Cross is offering evacuees assistance, Silva said.
The fire forced the closure of two lanes of eastbound Highway 80 until shortly before 5 p.m., according to the California Highway Patrol.
About 200 firefighters from Cal Fire and Solano, Yolo, Contra Costa and Napa counties responded to the blaze, Silva said.