While health experts are concerned that more-transmissible coronavirus variants could worsen spread of the disease -- and in some cases put up a measure of resistance to vaccines -- some are also encouraged by where vaccination efforts are headed.
"Overall, things are definitely getting better," Dr. Paul Offit, director of the vaccine education center at the Children's Hospital of Philadelphia, told CNN Friday.
An FDA advisory committee will meet about the request February 26. The panel will make a recommendation that the FDA will consider when it makes a decision about whether to authorize.
Johnson & Johnson has reported what appears to be lower efficacy than the other two vaccines in preventing moderate disease. But the company has emphasized its candidate was tested when certain virus strains were more prevalent -- and that it still was 85% effective against severe disease.
And experts have pointed to potential advantages: Unlike the Pfizer and Moderna vaccines, Johnson & Johnson's would take only one shot; it does not have to be stored in freezers; and it can be stored for three months at refrigerator temperatures.
The addition of a new vaccine will boost supply and allow more people to be inoculated faster, Offit and other experts have said.
And "the weather is going to get warmer, and when that happens, it makes it less easy for this virus to be transmitted," Offit said.
"I really do think that we will get on top of this by summer or late summer, because I think everything now is moving in the right direction," Offit said.
Dr. Ashish Jha, dean of Brown University's school of public health, also said Friday the vaccination situation in the US "is getting better."
"We're doing about 1.3 million (shots) a day (and) it got thrown off a little by the snowstorm," Jha said. "We can get to 2 (million a day), or even better than that."
Dr. Michael Osterholm, director of the Center for Infectious Disease Research and Policy at the University of Minnesota, has warned more contagious coronavirus variants still could spur significant surges of infections in the coming weeks, and that vaccines alone may not prevent this.
New York to offer vaccines to people with underlying conditions
New York may be the first state to offer vaccine access to people with comorbidity, or the simultaneous presence of two or more medical conditions, no matter their age.
"New Yorkers with comorbidities and underlying conditions exist throughout the state's population -- they're our teachers, lawyers and carpenters, in addition to the doctors who keep us safe every day, and they are a highly affected population," said Gov. Andrew Cuomo. "We're committed to vaccinating vulnerable populations that have suffered the most as we distribute a strictly limited supply of vaccines, and people with comorbidities are 94 percent of the state's COVID deaths."
The governor's office listed cancer, chronic kidney disease, pulmonary disease and heart conditions as some of the comorbidities and underlying conditions that the state will use to determine eligibility for the Covid-19 vaccine.
Starting February 15, doses reserved for hospital workers will be reallocated to those with comorbidities if hospital workers haven't used them, Cuomo said Friday.
About 75% of hospital workers have been vaccinated, and those who haven't will have until then to get their shots before access is opened to others.
Health departments will work with the state and the CDC to further determine which medical conditions qualify.
Model predicts steadily dropping death rate -- unless variants intervene
How quickly the variants spread versus the speed of vaccinations will be a key factor in the number of coronavirus deaths over the coming months, according to a forecast from the Institute for Health Metrics and Evaluation at the University of Washington.
Currently, IHME projects the country's number of Covid-19 deaths per day will drop steadily through June 1, in part because of vaccine rollouts and polls showing increasing percentages of Americans saying they're willing to get vaccines.
The US has averaged more than 3,230 Covid-19 deaths a day over the past week, not far from the record average of 3,357 set on January 13, according to Johns Hopkins University.
The IHME says its most-likely projected scenario would have deaths per day dropping to just under 2,000 by March 1; to 1,486 by April 1; to 1,245 by May 1; and 628 by June 1.
But in a worst-case scenario, including rampant variant spread, daily death rates could rise again by March -- and even exceed 2,600 a day by mid-April before dipping, the IHME says.
"If the variants are more widespread and people go back to their previous life faster" after being vaccinated, "then you get closer to our worst scenario that we put out," IHME Director Dr. Chris Murray told CNN's Anderson Cooper Friday night.
The Centers for Disease Control and Prevention has said the B.1.1.7 variant could be the dominant US strain in March. This variant first identified in the UK, is already on track to becoming dominant in hotspots like Florida and Southern California "within a few weeks," according to a testing company called Helix that has helped identify the largest share of US cases.
At least 618 cases of variants that are believed to be more transmissible have been identified across 33 states, according the CDC. The vast majority of those -- 611 -- are the variant first identified in the United Kingdom (B.1.1.7), with a few others being those first identified South Africa (B.1.351) and Brazil (P.1).
At least one case, that of a man who was chronically infected over months, indicates that variants aren't just coming from overseas but can be home grown in US patients.
Genetic tests showed that the patient, who had an underlying condition that weakened his immunity, had been infected with the same virus all along but that it had been evolving as it replicated.
"It was incredible," said Dr. Jonathan Li, who leads a lab at Brigham and Women's Hospital in Boston studying viruses and their mutations and had been called in to help study the patient's case.
For now, Covid-19 cases and hospitalizations in the US have been dipping after a holiday-era surge.
The country has averaged about 130,402 new Covid-19 cases a day over the last week -- down more than 47% since a peak average of more than 249,000 a day on January 8, according to Johns Hopkins data.
The number of Covid-19 patients n US hospitals Thursday was 88,688 -- the lowest since November 24.
CDC director: Guidance on reopening schools to be released in the coming week
The CDC will release guidance on school reopenings in the coming week, CDC Director Dr. Rochelle Walensky said during a White House briefing on Friday.
During the briefing, CNN asked whether one of Walensky's previous comments about schools -- that with proper distancing, masking and testing in place, schools could safely resume in-person classes even before all teachers get vaccinated -- was the CDC's official guidance.
"Our goal is to get children back to school," Walensky said Friday. "Schools should be the last places closed and the first places open. Our goal is to make sure in getting children back to school that we do so both with the safety of the children and the safety of the teachers" in place.
"Among the things that we need to do to make sure that schools are safe is to make sure that the community spread of the disease is down," Walensky said. "We are actively working on the guidance, the official guidance, which will be released in the week ahead."
So far, 24 states and Washington, DC, are explicitly allowing some teachers or school staff to receive the vaccine.
Biden administration plans to make 60 million at-home tests available this summer
The Biden administration announced on Friday that under the Defense Production Act, about 60 million at-home Covid-19 tests will be made available for the public by the end of this summer.
Those tests will be in addition to the at-home tests from the company Ellume that the administration previously announced, Tim Manning, Covid-19 supply coordinator, said during a White House news briefing.
"The country's well behind where we need to be in testing," Manning said.
"Over the coming weeks, the US government has plans to invest in another six suppliers to rapidly surge testing capability," Manning said.
On Monday, Andy Slavitt, the senior Biden White House adviser for Covid response, said during a White House briefing that the US Department of Defense and US Department of Health and Human Services are working with Australian company Ellume to provide more of its fully at-home Covid-19 tests to the United States and ship 100,000 test kits per month to the United States from February through July.
Now, "having 60 million more at-home tests available over the course of the summer is exactly what the country needs," Slavitt said during Friday's briefing.