It's the 10-year anniversary of the popular three-day event, which has a music lineup of 70 acts, including headliners The Who, Metallica and Gorillaz.
Single-day tickets are still on sale, but organizers say they're expected to sell out.
For tips on how to navigate the festival like a pro, watch the video above.
For a full list of road closures in San Francisco this weekend, click here.
Click here for more information and click here for the full lineup.
VIDEO: How to find your way around Outside Lands