The pope arrived at about 4 p.m. EST at Our Lady Queen of Angels school.
He is meeting with a select group of third and fourth graders at the school.
Twenty-four students from four Catholic schools throughout Harlem will sing for the Holy Father, as well as give presentations on projects relating to issues important to him, such as the environment and service to others.
LIVE UPDATES: Pope Francis in the U.S.
The lucky students got word of the visit over the summer.
The young students have been doing some planting and preparing some environmentally oriented projects to show Pope Francis.
Students from Saint Ann's School were hard at work sprucing up a section of East 110th Street.
The idea to beautify otherwise empty flower beds was Noah Rodriguez's, who was one of six Saint Ann students who will visit the pontiff when he visits in Harlem.
"My first reaction was like, yes," Noah said.
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