The fire happened at 1000 Howard St. just after 2p.m.
Officials say at least eight people were injured, four of whom were taken to area hospitals; and 15 were rescued.
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The third and fourth floors of the building were impacted.
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Firefighters also say seven cats and dogs were rescued.
UPDATE: FIRE UNDER CONTROL 3rd and 4th floor affected--15 rescued-- 8 injured (4 taken to hospitals)- 7 cats and dogs rescued- GOOD NEWS EVERYONE AND EVERY PET WILL BE OKAY- Fire is under investigation- AVOID AREA FOE NEXT 4 hours and the next delays in traffic https://t.co/sGVHBPCfie pic.twitter.com/aErJfrqcEe— SAN FRANCISCO FIRE DEPARTMENT MEDIA (@SFFDPIO) February 26, 2022
The cause of the fire is under investigation.