The 19-year-old woman, originally from Chapel Hill, N.C., has not been heard from by friends or family since the end of last month.
According to authorities in Orange County, N.C., Sydney West has lived in the San Francisco area since late August and attends UC Berkeley.
The North Carolina sheriff's department says the woman is likely dressed in dark shorts, slip on Vans shoes and has her hair in a ponytail.
RELATED: University of California requires flu vaccination for students, faculty and staff
She's described as 5-foot-10-inches tall, 130 pounds and has blue eyes and light brown hair
Authorities say she may have a black backpack.
"Her last known location is in downtown San Francisco near Crissy Field, close to the Golden Gate Bridge," the sheriff's department said in a statement.
Those with information on her disappearance are asked to call San Francisco police at (415) 575-4444 or text a tip to TIP411. Any tip sent via text must begin with "SFPD."
Those with information can also contact Investigator Ashley Woodlief at (919) 245-2909 in the Orange County Sheriff's Office in North Carolina.