Jennings, who was injured during Saturday night's loss to the Bucks, will undergo surgery. No timetable is being placed on the guard's return at this time, the team announced.
Jennings took to Twitter earlier Sunday and seemed to allude to the amount of time he will be sidelined.
Jennings fell to the floor after planting on his left leg while guarding an inbounds pass Saturday. He immediately clutched the leg above his sneaker while writhing on the floor in pain.
The 6-foot-1 guard has appeared in 41 games this season, averaging 15.4 points, 6.6 assists and 1.1 steals in 28.6 minutes per game.
Brandon Jennings Out For Season
ESPN NBA insider Bradford Doolittle breaks down how Brandon Jennings' season-ending injury will impact the Pistons.
Jennings Injured In Pistons' Loss
Brandon Jennings left the game in the third quarter with a lower left leg injury in the Pistons' 101-86 loss to the Bucks.