Sunday, 8:20 p.m. EDT, NBC
OPENING LINE: 49ers by 4 1/2, according to FanDuel SportsBook.
AGAINST THE SPREAD: Indianapolis 4-2; San Francisco 1-4.
SERIES RECORD: Colts lead 26-18.
LAST MEETING: Colts beat 49ers 26-23, OT, on Oct. 8, 2017 in Indianapolis.
LAST WEEK: Colts beat Texans 31-3; 49ers had bye, lost at Cardinals 17-10 on Oct. 10.
COLTS OFFENSE: OVERALL (15), RUSH (11), PASS (16), SCORING (19).
COLTS DEFENSE: OVERALL (20), RUSH (14), PASS (20), SCORING (11).
49ERS OFFENSE: OVERALL (14), RUSH (12), PASS (14), SCORING (17).
49ERS DEFENSE: OVERALL (6), RUSH (18), PASS (7), SCORING (15).
TURNOVER DIFFERENTIAL: Colts plus-7; 49ers minus-5.
COLTS PLAYER TO WATCH: DeForest Buckner. The 2020 All-Pro defensive tackle was traded by San Francisco to Indy in March 2020. He's acknowledged this has not been the start he envisioned, for himself or the team, but now he has a chance to make a statement against his former club.
49ERS PLAYER TO WATCH: QB Jimmy Garoppolo. Garoppolo is expected to return after missing one game with a right calf injury. Garoppolo wasn't sharp in his last two starts, completing 61.9% of his passes with three TDs, two INTs and an 84.2 passer rating.
KEY MATCHUP: Colts RB Jonathan Taylor vs. 49ers LB Fred Warner. Warner was so impressed with Taylor when they played in college back in 2017 that he told teams at the combine the following year that Taylor was the best player he faced in college. Taylor has lived up to that billing in his second season in the NFL, averaging 5.1 yards per carry.
KEY INJURIES: Indy put oft-injured receiver Parris Campbell on IR after he hurt his foot on a 51-yard TD catch. ... The Colts activated three-time All-Pro G Quenton Nelson from IR. ... Indianapolis also will be without WR T.Y. Hilton (quadriceps), T Braden Smith (foot/thumb), S Julian Blackmon (Achilles tendon) (sprained ankle) and DE Kemoko Turay (groin). ... K Michael Badgley has replaced Rodrigo Blankenship (hip). ... Niners backup QB Trey Lance will miss the game with a sprained left knee. ... San Francisco LT Trent Williams is doubtful with an ankle injury. ... San Francisco slot CB K'Waun Williams is expected back after missing two games with a calf injury.
SERIES Game notes
The Colts have won the last four meetings in the series, including a 26-23 OT win in 2017 that dropped San Francisco to 0-5 in coach Kyle Shanahan's first season. ... San Francisco's last win came in 2001 when the Niners intercepted Peyton Manning four times in a 40-21 victory. That loss led to former coach Jim Mora's "playoffs" rant.... Colts QB Carson Wentz has won both career starts against San Francisco, including a come-from-behind 25-20 win last October for Philadelphia.
STATS AND STUFF: Wentz can tie Andrew Luck, Peyton Manning and John Unitas' franchise record for most consecutive games with a passer rating of 115.0 on Sunday. He's had three straight. ... Taylor ran for 145 yards in last week's victory over Houston and had 116 yards receiving the previous week at Baltimore. In his last 13 games, Taylor has 1,291 yards rushing and 12 TD runs. ... Indy LB Darius Leonard has had a takeaway in four consecutive games. The Colts have forced at least one turnover in seven straight. ... The Colts are tied with Arizona for the most fumble recoveries this season (7) and the Los Angeles Rams for fewest penalties (24). ... San Francisco has lost three straight games. ... The Niners are 1-6 at Levi's Stadium the past two seasons. ... San Francisco WR Deebo Samuel had 71 yards from scrimmage and his fourth career TD run in Week 5 loss to Arizona. Samuel has at least five catches in four of five games this season. ... Niners DE Nick Bosa's five sacks are the most through five games for the franchise since Bryant Young had six in 2005.
FANTASY TIP: San Francisco RB Elijah Mitchell has gotten the bulk of the carries when healthy. He had 36 carries for 146 yards in the two games he played with Garoppolo as starter and could get a heavy load again.
Injuries will doom 49ers vs. Colts
Ryan Clark and Mina Kimes both see injuries as too big of a problem for the 49ers against the Colts.