Officials say the fire burned 75 acres along I-580 and Mountain House Parkway, between Livermore and Tracy.
PHOTOS: Crews battling brush fire along I-580
The fire broke out at 2:19 p.m. in the vicinity of Interstate 580 and the North Flynn Road off-ramp.
An accident involving at least three cars was reported on eastbound I-580 near Grant Line Road.
Officials say no injuries were reported and no structures were threatened.
Bay City News contributed to this story.