49ers OT Joe Staley, safety Jimmie Ward suffer serious injuries

PHILADELPHIA -- Six San Francisco 49ers left Sunday's game against the Philadelphia Eaglesbecause of injury and did not return, and there are two -- left tackle Joe Staley and free safety Jimmie Ward -- who could be missing extended time.

Staley did not return to the Bay Area with the team after suffering a right eye injury in the second quarter of a 33-10 loss to the Eagles. A source tells ESPN's Adam Schefter that Staley fractured his orbital bone, but expects to play again this season.

Staley suffered a gash under his right eye when he was blocked by Eagles defensive tackle Fletcher Cox as he attempted to tackle Eagles cornerback Jalen Mills, who was returning an interception for a touchdown.

The NFL is reviewing the play by Cox for potential discipline and possible suspension.

Veteran Zane Beadles, who entered for right tackle Garry Gilliam when he suffered a game-ending knee injury, moved to the left side, with rookie Erik Magnuson stepping in on the right side.

Ward, meanwhile, suffered what coach Kyle Shanahan confirmed after the game was a fractured arm. Shanahan was unsure where the fracture was in the arm, though Ward's injury was initially announced as a forearm issue.

Rookie Adrian Colbert replaced Ward at free safety and finished the game.

Receiver Pierre Garon (neck), defensive tackle D.J. Jones (knee) and defensive end Solomon Thomas (knee) also left the game and did not return, though Shanahan had no further updates after the game.