Cantor Technology released the spreads for every NFL game in Weeks 1-16. Below are the lines for San Francisco 49ers games.
Week 1
Los Angeles Rams (-2, 46) at San Francisco
Week 2
San Francisco at Carolina Panthers (-11.5)
Week 3
San Francisco at Seattle Seahawks (-14)
Week 4
Dallas Cowboys (-3) at San Francisco
Week 5
Arizona Cardinals (-6) at San Francisco
Week 6
San Francisco at Buffalo Bills (-7)
Week 7
Tampa Bay Buccaneers at San Francisco (PK)
Week 8
BYE
Week 9
New Orleans Saints at San Francisco (PK)
Week 10
San Francisco at Arizona Cardinals (-10.5)
Week 11
New England Patriots (-6) at San Francisco
Week 12
San Francisco at Miami Dolphins (-5)
Week 13
San Francisco at Chicago Bears (-5)
Week 14
New York Jets at San Francisco (PK)
Week 15
San Francisco at Atlanta Falcons (-5)
Week 16
San Francisco at Los Angeles Rams (-5.5)