Despite multiple reports about a potential snag, Bertuzzi's lawyer Geoff Adair confirmed Tuesday the sides have reached a "firm and binding settlement" and the case was "settled in its totality."
Emails to Tim Danson, Moore's lawyer, have not been returned.
Details of the settlement will not be made public, a source told ESPN.com.
"Suffice it to say, Todd Bertuzzi is happy this has arrived at a resolution, as I'm sure all parties are," Adair told ESPN.com when reached by phone early Tuesday evening.
Moore was suing Bertuzzi and the Canucks for $38 million for a 2004 on-ice hit by Bertuzzi that ended Moore's career. Then a Colorado Avalanche player, Moore sustained a concussion and three fractured vertebrae and never played again.
According to a report out of Canada earlier this summer, Moore's lawyers sought an increase in damages to $68 million. The case was scheduled to go to trial on Sept. 8.
Moore was on the receiving end of a sucker punch to the head from behind from Bertuzzi that allegedly was made as retribution for a hit made by Moore on Canucks captain Markus Naslund in a previous game. Bertuzzi attacked Moore in a rematch between the teams on March 8, 2004, and left Moore with the broken vertebrae and concussion.
In March, a day before the 10th anniversary of the play, Moore told The Canadian Press he still has headaches and low energy.
"I lost my entire career in my rookie year," he said in recent years. "I think any player put in that situation would do the same thing. I can't recover anything else. I can't recover my career, the experience of living out my dream from the time I was 2½ years old of playing in the NHL."
The 35-year-old Moore is the brother of New York Rangers forward Dominic Moore.
Bertuzzi was suspended by the league 13 regular-season games, plus the 2004 Stanley Cup playoffs. He was reinstated 17 months later, after the year-long lockout.
The 39-year-old veteran, played for the Detroit Red Wings for the past five seasons, but the unrestricted free agent remains unsigned for the coming season.
Information from The Associated Press was used in this report.