Caltrain officials say just before 1:40 p.m. a train collided with a vehicle, killing the driver.
Emergency personnel is on scene including transit police and rail officials.
Trains are currently stopped in the area and a bus bridge has been set up between Hayward Park and Millbrae with the help of SamTrans. Officials say all Caltrain tickets and passes are being honored by SamTrans.
Authorities have not yet released details of what led up to the deadly crash.
This accident comes less than a week after a person was fatally struck by a Caltrain last Friday while trespassing on the tracks near the Burlingame station.
RELATED: Person fatally struck by Caltrain while trespassing on tracks near Burlingame station, officials say
Stay with ABC7 News for the latest details on this developing story.