Videos posted to social media showed medical personnel surrounding the rock legend after he collapsed at Pine Knob Music Theatre, an outdoor amphitheater in Clarkston, about 40 miles northwest of Detroit.
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In a press release, Santana's manager Michael Vrionis said he was taken to the hospital for observation and is doing well.
"The show for tomorrow, July 6, at The Pavilion at Star Lake (formerly the S&T Bank Music Park) in Burgettstown, PA. will be postponed to a later date. More details to follow through Live Nation," Vrionis said.
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Temperatures in Clarkston reached up to 90 degrees Tuesday, nearly 10 degrees above average, according to CNN meteorologist Robert Shackelford.
"He had just started a song that was about joy and love," concertgoer Alisa Zee told CNN. "He called for healing for the world. It was during that song that he collapsed."
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As medical personnel attended to Santana, the stage crew held up a black tarp to block the view of the stage. As he was removed off the stage, fans are heard in a video cheering for the musician. Zee said the artist waved at fans as he was taken off stage.
"Carlos was taken to the emergency department at McLaren Clarkston for observation and is doing well," reads the statement on his Facebook page.
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Legendary musician Carlos Santana, family honored by community with mural in SF's Mission district
Following the incident, Santana also posted a short message on Facebook, where he thanked his fans for their "precious prayers."
"To one and all. Thank you for your precious prayers. Cindy and I we are good just taking it easy. Forgot to eat and drink water. So I dehydrated and passed out. Blessings and miracles to you all," he wrote.
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The musician was set to perform with Earth, Wind and Fire on Wednesday night in Pennsylvania, but that concert has been postponed, according to the statement.
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Santana performed Monday as part of CNN's 'The Fourth in America' concert.
Santana is a longtime Bay Area resident, he grew up in San Francisco's Mission District where he graduated from James Lick Middle School and went on to Mission High School.
CNNWire contributed to this report.