The surveillance video shows several men coming out of the home with bags and loading them into a car.
An SUV was also stolen from the garage.
Police say they think the suspects are responsible for other burglaries throughout the region.
They believe it's "criminal tourism" and blame sophisticated burglary crews from South America.
VIDEO: Hillsborough police investigate series of safe burglaries; may be linked to 'tourism theft groups'
Police investigate series of safe burglaries in Hillsborough