Lafayette police arrested 54-year-old Kyle Ann Wood last night at her home in Pleasant Hill.
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Investigators received reports of alleged inappropriate and unlawful relationships Wood had with two minors between 1996 and 1998 when she was a teacher at Acalanes High School.
Wood is currently a PE teacher at Miramonte High School in Orinda.
The district attorney filed felony sex charges against Wood. She was booked into jail and is being held on $150,000 bail.
Lafayette police are asking anyone with additional information on the case to contact detectives.