RELATED: Battle over navigation center in San Francisco's Embarcadero is not over
The center near the Bay Bridge will house up to 200 people.
Neighbors who have fought against the Navigation Center argue it will bring more drugs and crime to the area.
RELATED: Pier 39 business owner to San Francisco leaders: Stop ignoring issues of homelessness, dirty streets
Police have said they will set up a two-block safety zone around the center to keep loiterers, homeless encampments and drug use out of the area.