It happened around 5:30 p.m. on westbound I-580 and closed part of the freeway near High Street.
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Traffic headed toward San Francisco was diverted onto Highway 13.
RELATED: 4 injured in shooting on I-580 in Oakland, eastbound lanes shut down, CHP says
The shooting victim was driving a white sedan which could be seen from SKY7 while it was over the scene.
Several people driving on 580 called police reporting that two people were shooting at each other.
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It's believed the gunfire came from someone with a semi-automatic gun inside a silver car.
The CHP is still investigating what led to the shooting.
Stay with ABC7 News for the latest details on this developing story.