The crash happened before Highway 92 and after Winton Ave. The truck has two trailers, one of which was seen on its side.
As of 6:30 a.m., only one lane remained blocked.
MORE: Big rig overturns, leaks fuel in Alameda Co. solo crash after driver apparently fell asleep
On Thursday, a separate big rig crash impacted the morning commute. It also happened in Alameda County, when a driver apparently fell asleep at the wheel and hit the median, causing the truck to overturn and spill fuel.
Stay with ABC7 News for updates on this developing story.