The mural, located on Market Street between Sixth and Seventh streets, shows only part of Williams' face, focusing on his eyes. His gaze casts a knowing glance on the pavement.
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An artist from Argentina spent six days on the mural and finished the vibrant piece on Sunday.
RELATED: SF officials vote to name meadow after Robin Williams
He says he picks subjects important to the community the work is for.
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Williams lived in the Bay Area as a teen and began his comedy career here.
He died in 2014 after struggling with depression and addiction.
For more stories, photos, and video on Robin Williams, visit this page.
VIDEO: Anthony Bourdain remembered with a new mural
Anthony Bourdain remembered with new mural