The motorcyclist, a man in his 30s, was headed southbound on Highway 101 to eastbound I-80 about 3:30 a.m. when he was involved in a collision and was thrown from his motorcycle, according to the California Highway Patrol.
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Authorities say he may have been trying to avoid a DUI crash and swerved off the connector, landing on a moving vehicle below on the westbound I-80 to southbound Highway 101 ramp.
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That car stopped in lanes of traffic and was hit by another car being driven by a suspected DUI driver, the CHP said.
The motorcyclist was pronounced dead at the scene.
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A Sig-Alert was issued at 4 a.m. for the southbound Highway 101 connector to eastbound I-80. The roadway reopened about 8:45 a.m.
The CHP is asking anyone who may have witnessed the crashes to contact them at (510) 557-1094.