It happened Friday afternoon in the area of Third Street and Palou Avenue.
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When officers arrived, they found a 21-year-old man suffering from gunshot wounds, police said.
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He was transported to the hospital where he later died.
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Investigators marked several bullet casings in front of Naughty Boy clothing store on Third Street.
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A second victim, a 29-year-old man, was taken to the hospital with non-life-threatening injuries.
No arrests have been made.