You want to stay away from the second floor of your home. Most damage in tornadoes occurs on the top floor.
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You want to go to the lowest level of your house. Make your way to your most interior hallway or bathroom.
You want to avoid windows. You are trying to put as many barriers between yourself and the outside would as possible.
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Make sure you have shoes on -- in case you have to walk on debris later -- and put pillows and cushions on top of you for protection.
Watch the latest AccuWeather forecast and take a look at recent weather stories and videos.