President Donald Trump announced "major combat operations" against Iran on Feb. 28, with massive joint U.S.-Israeli strikes attack targeting military and government sites, officials said.
Ayatollah Ali Khamenei was among those killed in Tehran on the first day of strikes, with his son Mojtaba Khamenei later chosen to succeed him. Iran has responded with missile and drone attacks targeting Israel, regional U.S. bases and multiple Gulf nations. Iran is also attempting to block some shipping traffic through the Strait of Hormuz.
Israel is also intensifying its long-running strike campaign against the Iran-backed Hezbollah militia in Lebanon and expanding its ground operations in the south of the country.
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Iran has reported that a projectile hit the premises of the Bushehr Nuclear Power Plant, according to the International Atomic Energy Agency.
"According to Iran, there was no damage to the NPP itself nor injuries to staff, and the condition of the plant is normal," the IAEA Director General Rafael Mariano Grossi said in a post on X.
Israeli authorities reported damage in the Tel Aviv region after an Iranian missile barrage on Tuesday.
Israel Police said in a post to X that its officers were responding to "scenes involving fallen munition. Damage has been caused at the scene."
The Israel Defense Forces reported "several sites in central Israel where reports of impacts have been received."
More than 2,100 children have been killed or injured across the Middle East since the war in Iran began, according to UNICEF.
The fatalities include 206 children in Iran, 118 in Lebanon, four in Israel and one in Kuwait, according to UNICEF.
"These are reported figures, and they are expected to rise as the violence continues," UNICEF said in a release. "That is an average of approximately 87 children either killed or injured every day since the beginning of the war."
The Trump administration is not confirming if and when in-person talks will take place between U.S. and Iranian officials in the coming days, calling the situation "fluid."
"These are sensitive diplomatic discussions, and the United States will not negotiate through the press. This is a fluid situation, and speculation about meetings should not be deemed as final until they are formally announced by the White House," White House press secretary Karoline Leavitt said in a statement to ABC News.
When asked if U.S. envoys Steve Witkoff and Jared Kushner and Vice President JD Vance were expected to travel to Islamabad, Pakistan, later this week to meet with Iranian officials -- as Reuters has reported -- the State Department referred ABC News to the White House.
Vance's office has not responded to requests for comment.
Pakistan has positioned itself as a mediator between the U.S. and Iran. A Pakistani official familiar with the negotiations said there are "several proposals" floating around regarding the next steps for talks and that an in-person meeting in Islamabad is on the table. Turkey and Egypt are also helping to facilitate the talks between the U.S. and Iran, the official said.
The official said the talks would likely take place within the next five days in accordance with President Donald Trump's social media post, in which he said strikes on Iranian power plants were "paused" for the next five days as Tehran and Washington engage in diplomatic negotiations. The official cautioned that nothing is final as of yet.
