An email was sent by Cinemark to its customers announcing the theater's closure after Thursday.
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Cinemark's website confirms there are no movie showings scheduled for Friday or beyond.
A Cinemark representative provided this statement to ABC7 News:
"Cinemark can confirm it has decided to permanently close the Century San Francisco Centre 9 and XD theater shortly before the conclusion of its lease term following a comprehensive review of local business conditions."
It's the latest blow to the downtown shopping district.
Westfield just announced on Monday its giving up the mall, transferring management to its lender.
There have also been numerous closures of other businesses in the area.
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Despite the challenges, Mayor London Breed is looking to what could be coming next.
"These venues are going to still remain open," she said. "But have a conversation with the lenders, the business community and others including our educational institutions. UCSF, Berkeley, Stanford, who have an interest in expanding in our space."
Before the closure of Cinemark, Westfield said the San Francisco Centre's occupancy level had dropped to 55%.
Nationally, Westfield's occupancy rate averages around 93%.
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