Protesters were seen on the platform near the Van Ness exit on Highway 101.
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Police eventually got them to leave peacefully.
The marchers also took over Market Street as they marched from City Hall to the freeway.
Demonstrators are calling for a permanent cease-fire in Gaza.
"A temporary cease-fire is absolutely not sufficient. You can't pause s genocide. There is only stopping it.," said Wassim Hage, one of the pro-Palestinian supporters.
MORE: Around 50 protesters demanding cease-fire briefly shut down Golden Gate Bridge, CHP says
Around 50 protesters demanding cease-fire briefly shut down Golden Gate Bridge, CHP says
The United States is proposing a temporary cease-fire in Gaza to allow humanitarian aid to get to Palestinian refugees.
The Biden administration is also critical of an Israeli plan to launch a ground offensive in Rafah - where many refugees have fled.
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