Mayor Breed acknowledged the city's downtown area will not be the same as before the COVID-19 pandemic.
MORE: SF mayor reveals 'Bloom SF' plans to welcome workers back downtown
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She says she's had conversations with Benioff about how his flexible work policies are impacting the city.
MORE: EXCLUSIVE: Marc Benioff talks Dreamforce, relocating Texas employees in wake of abortion law
Salesforce is the city's largest private employer.
Mayor Breed notes Benioff's contributions to schools and other causes, but says it's a real problem the Salesforce Tower is empty.
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In regards to Elon Musk, the mayor said, "The person who got a ton of tax breaks in California and decided to take that money and run."
Musk moved Tesla's headquarters from the Bay Area to Texas in 2021.
Editor's Note: A later version of this story was added to our video player above
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