Mayor Breed says Friday's burglary is "detrimental to our city."
"What happens when people vandalize and commit those level of crimes in San Francisco. We not only lose those businesses, we lose those jobs. We lose that tax revenue that helps to support our economy that helps to support many of the social service programs that we have in the city in the first place. We can't allow that to happen," she said.
"What you saw was horrible. But you also saw the men and women of the San Francisco Police Department who were here on site in Union Square yesterday."
At least eight people have been arrested in connection with the burglaries at a Louis Vuitton store and surrounding businesses in San Francisco, according to Chief Scott.
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"San Francisco police officers responded to calls of numerous burglaries not only in Union Square but the surrounding area," he said.
SF mayor, police chief address looting, vandalism after robbery at Union Square
Police say around 8:10 p.m. on Friday, officers responded to reports of possible looting and vandalism to retail establishments in the Union Square Area.
Chief Scott listed at least 10 businesses that were targeted including Bloomingdale's, Burberry and Louis Vuitton.
"This is unacceptable," the chief added.
Social media video shows some of the chaos that has unfolded there Friday night - smashed store windows, police and people running in the street.
RELATED: Video shows decimated San Francisco Louis Vuitton store after massive smash-and-grab robbery
Video shows empty SF Louis Vuitton store ransacked by thieves
The store in Union Square looked completely empty, apparently ransacked by robbers.
Mayor London Breed announced changes to put an end to these types of crimes.
"Last night what we saw was horrible," she said. "We're gonna be making some changes to Union Square and how cars are able to access. There will be limited access in terms of when you come to this area."
RELATED: Proposal allowing SF deputies to provide retail security to combat theft paused over concerns
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The thieves also tried to get into the Fendi store by smashing one of the windows but could not get in.
WATCH: Video shows stream of handbag thieves sprinting out of San Francisco Neiman Marcus
Video shows handbag thieves sprinting out of SF Neiman Marcus
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Anyone with information is asked to contact the SFPD at 415-575-4444 or text a tip to TIP411 and start the message with SFPD.
This comes as San Francisco is dealing with an uptick in organized retail theft across the city, causing several stores to permanently close.
Marisa Rodriguez, Executive Director Union Square Alliance, provided ABC7's Cornell Barnard with this statement:
"After such a challenging time, San Franciscans and visitors are ready to come out and celebrate the holidays in Union Square. Even after the events of last night, people are out and about enjoying the holidays in the square. We are certainly grateful for the support of the San Francisco Police Department for their strong presence during the holiday season, and for being at the ready to quickly arrest suspects last night.
The type of organized vandalism and theft that swept through Union Square must stop and must stop now. We must all lean in-- the City, stakeholders, and community members-- to prevent incidents like this from happening again. This is a time for working together to provide assistance and find real and lasting solutions. Union Square is an international symbol of the best of San Francisco, and we're committed to keeping it that way. We will work with the Mayor and the Police Department to solve these issues. Union Square is an international symbol of the best of San Francisco, and we're committed to keeping it that way."