The deadly collision happened at Highway 237 near Mathilda Ave. in Sunnyvale around 4 a.m.
The CHP said a silver 2021 Honda Civic was driving eastbound on the westbound lanes before crashing into a red 2017 Honda Civic.
Both drivers were killed, the CHP said. There were no additional passengers in both vehicles.
All westbound lanes were briefly closed for 30 minutes, and fully reopened several hours later.
The driver of the wrong-way vehicle was not ID'd, but was described as a Hispanic man in his mid 20s to early 30s.
The other driver was described as a white man, also in his mid 20s to early 30s.
It's unknown if alcohol or drugs played a factor.
OAKLAND-Not Fatal
Over in the East Bay, a wrong-way driver heading east on westbound Interstate 580 near the Seminary Avenue off-ramp in Oakland caused a collision that resulted in the closure of all westbound lanes Sunday morning, according to the California Highway Patrol.
The CHP was alerted to the incident at a little past 7 a.m. when witnesses called to report that the driver of a Ford F-150 pickup truck was heading the wrong way and intentionally trying to run head-on into other vehicles, according to the CHP.
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The F-150 eventually collided with a Ford F-250 owned by the City of Oakland, prompting a SIG alert and road closure.
The driver of the F-150 was taken to Highland Hospital with major injuries and the driver of the F-250 was taken to the same hospital with minor injuries, said CHP spokesperson Officer Karina Oseguera.
All lanes were reopened to traffic at about 8:30 a.m., Oseguera said.
MORE: 1 killed following wrong-way crash in Marin, authorities say
1 killed following wrong-way crash in Marin, authorities say
Marin
On Saturday, a 22-year-old driver from Santa Rosa crashed into another vehicle in Marin at around 3:30 a.m. The wrong-way driver was pronounced dead at the scene, authorities said.
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The other driver, identified as Trey King, 30, from Novato, has sustained major injuries and is in the hospital.
MORE: 1 woman dead, 2 hurt in wrong-way crash on I-280 in Woodside; driver arrested, CHP says
1 woman dead, 2 hurt in wrong-way crash on I-280 in Woodside, CHP says
Woodside
On Saturday afternoon, a white Ford sedan drove north in the southbound lanes of I-280 in Woodside crashing head-on into a black BMW SUV.
It happened just after 2:30 p.m.
The driver of the BMW, a 54-year-old woman from San Francisco, was pronounced dead at the scene by emergency personnel, the CHP said.
Her name has not been released.
A 14-year-old boy, who was in the front passenger seat of the BMW, was taken to Stanford Medical Center with major injuries, the police said.
His name was not disclosed.
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The driver of the Ford, Constellatia A. Martin, 24, of Campbell, was arrested and taken to Stanford Medical Center with major injuries, police said.
It is unknown if drugs or alcohol were involved at this time, police said.
Bay City News contributed to this report
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