People dressed in Santa suits will take part in bar crawls throughout various neighborhoods.
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But where Santa goes, trouble sometimes follows.
Last year during SantaCon, two women were arrested for felony vandalism and battery, after they were caught on video trashing a restaurant on Polk Street.
RELATED: Women caught on camera in restaurant rampage during SF SantaCon turn themselves in
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Event organizers are urging people to be respectful.
One Santa meeting spot is Union Square, where people are asked to bring a new, unwrapped toy to donate to the San Francisco Fire Department.
Rain and wind is forecast throughout the day on Saturday, but SantaCon will happen rain or shine.
VIDEO: Watch your ABC7 AccuWeather forecast here