These two teams last met in January's NFC title game, where the 49ers fell 20-17 to the eventual Super Bowl champs. Despite that victory, the team has struggled in recent years against San Francisco. The Rams have recorded six consecutive regular-season losses against the 49ers -- and four of those have been decided by one score.
Here are some of the best ManningCast moments from Week 4:
Von Miller may need to reassess his evaluation of Steph's playing style.
Hurts, the NFC MVP of the month, has been in the end zone fairly often this season, so he's had plenty of time to work on his dance moves. According to Eli, Peyton can relate.
Peyton was in familiar territory with his wristband.
Eli brought on an unofficial special guest for the night.