The crash occurred on northbound state Highway 1 at Clarendon Road when a Toyota Prius traveling southbound in the northbound lanes struck a Chevy Silverado.
Traffic was being diverted at Sharp Park Road while the investigation was underway. The northbound lanes reopened to traffic around 10 a.m.
A Sig-alert was issued due to the incident.
The crash was first reported at 4:13 a.m.
Less than a week ago, a father of seven children was killed by suspected wrong-way driver on Highway 101 in San Francisco.
Bay City News contributed to this report.