Officials said between 25 to 50 vehicles were involved and 30 patients were on scene with 22 suffering minor injuries, seven with undetermined injuries and one 22-month-old child air lifted to a hospital in critical condition.
A horse died at the scene.
Video from the scene showed traffic at a standstill and one car burning; Los Angeles Fire said several cars were on fire, but all flames had been extinguished.
The crash occurred shortly before 3 p.m. near Gorman School Road.
Thick fog over the grapevine on the Golden State Freeway 5. Several pileups causing major delays southbound near exit 202. pic.twitter.com/jkzAr6uD0V— Jen Hughes (@JenPhoLil) March 23, 2019
Traffic was limited to one lane on the southbound side as multiple lanes were closed. After major delays, lanes reopened at approximately 6:35 p.m., according to the California Highway Patrol.
Officials said foggy conditions made visibility an issue. CHP confirmed no one was arrested for DUI.
Kern County Fire was on scene assisting.