Mayor London Breed and House Minority Leader Nancy Pelosi joined state and regional leaders at the ceremony.
OVER IT: Exclusive peek inside San Francisco's 'Grand Central Station of the West'
On Saturday, a neighborhood block party will officially open to the public from 12 p.m. to 4 p.m.
Starting on Sunday, the transit center will be the hub for bus service serving AC Transit, Amtrak, Greyhound, and Westcat.
Muni buses have already been using the center.
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