The demonstration, which was initially peaceful, originated as an organized event at Pan Pacific Park where as many as 10,000 people gathered and eventually spilled out onto nearby streets. The marchers made their way west on Third Street before gathering at the Fairfax Avenue intersection.
Traffic was initially snarled before the crowded streets were eventually shut down.
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Multiple patrol vehicles were also set on fire during the protest, with many marked with graffiti. Buildings in the Fairfax District area were also tagged.
Two officers were struck by flying debris during the protests in the Fairfax District and were taken to a hospital.
Officers formed a skirmish line around 6:30 p.m. near Third Street and Fairfax Avenue to push protesters out of the area. Police later brought in large, military-style vehicles to clear the streets.
Just before 7 p.m., police responded to the Nordstrom store at The Grove in Los Angeles after it was broken into.
A kiosk for the Los Angeles Police Department at The Grove was set on fire.
Some sign-carrying protesters chanting "Eat the rich'' came to Beverly Hills' famed shopping street Rodeo Drive.
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Chaotic scenes erupted across the area. Looters were seen destroying an ATM on Melrose Avenue, which was eventually taken away by a group of looters, as a fire burned about a block away near the Adidas store. Others were seen smashing store fronts, including at least one person who took a hammer to a store window.
Luxury stores on Rodeo Drive were also burglarized and vandalized.
Downtown Los Angeles
AIR7 HD was over downtown Los Angeles around 11 p.m. as a handful of protesters were seen on the streets despite the curfew. However, the scene was a stark contract from the previous night when violent protests led to 500 arrests.
The sound of sirens echoed through the streets as police cruisers raced toward acts of violence.
LAPD officers armed with non-lethal weapons dispersed people who were seen roaming the streets, taking some people into custody. Authorities also blocked the streets to control the movement of demonstrators.
Five LAPD officers on Friday were injured in confrontations between police and protesters, officials said. One suffered a broken hand, another a head injury. Both of those officers are expected to recover. The specific injuries sustained by the other three were not immediately known.
More than 400 arrested, 5 officers hurt amid clashes in downtown Los Angeles
Local and state officials' response
Mayor Eric Garcetti announced a curfew for all of Los Angeles from 8 p.m. Saturday to 5:30 a.m. Sunday. Beverly Hills, Culver City, Pasadena and West Hollywood also enacted a curfew due to safety concerns.
The mayor joined many other city officials Saturday in sympathizing with demonstrators while also appealing for calm. "With liberty comes responsibility to be able to peacefully protest,'' Garcetti said.
"For that one or two percent of the protesters who think that (violence) is the way to make a statement, do not do a disservice to the memory of George Floyd (and) the folks who have died at the hands of the brutality that we all stand against,'' Garcetti said.
The mayor told reporters he had no plan to call for National Guard troops to assist police. "This is not 1992. We are not going to evoke what happened then and call in the National Guard. But that's on all of us. Let's all of us de-escalate,'' he said.
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However, hours later, Garcetti said he asked Gov. Gavin Newsom to put the California National Guard on standby.
Authorities say there was increased levels of widespread violence, crime, vandalism and assaults on police officers as the protests took a dark turn.
Officials say the National Guard was en route to help police quell the violence.
Los Angeles City Council President Nury Martinez issued a written statement on the protests and vandalism.
"When the National Guard has to be called in because anarchy has taken over our streets, that is not progress, that is not righteousness, that is just destruction," Martinez said. "These protests across America, including here in Los Angeles, are about our country's biggest and most unresolved sin - racism. We need to be focused on change through peaceful and fervent protest. Unfortunately, that is not what we are seeing tonight. We need to destroy hate, not our communities."
The Associated Press and City News Service contributed to this report.