The fire is located near the intersection of Broadway and Sharon Street on the western edge of the city near state Highway 29.
A Vallejo fire spokesperson said the commercial building likely houses a large number of vehicles.
Firefighters from American Canyon, Benicia and Fairfield are assisting Vallejo firefighters.
A lumber yard is located west of the fire location and a mobile home park is one block north, so firefighters are taking preventative measures so the flames do not spread.
There are no further details at this time.
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