Police say the collision happened just before 2:30 a.m. near McKee Road and Jose Figueres Avenue.
The pedestrian, who has not been identified, died at the hospital, according to police.
Eastbound McKee Road is expected to be closed for "several hours" between Joe Figueres Avenue and Jackson Avenue because of the crash.
Police have not provided details on the driver involved in the collision.
Units are currently in the area of McKee Rd and Jose Figueres investigating a collision involving a vehicle and pedestrian. The pedestrian has been declared deceased at the scene.— San José Police Media Relations (@SJPD_PIO) July 14, 2021
TOC 2:27 AM
Press release forthcoming. pic.twitter.com/rmHh6rDlfG