The driver, Derek James Copley, 20, crashed his Ford F-150 into the center divider of northbound U.S. Highway 101 at Asti Avenue in heavy fog around 1:20 a.m. Sunday, CHP Officer Jon Sloat said.
The Ford came to rest in the middle of the freeway where it was struck by a northbound Mitsubishi sedan driven by 19-year-old Cody Trettin of Cloverdale, Sloat said.
Trettin helped Copley out of the Ford and the two men pushed both vehicles off the road, Sloat said.
A northbound Honda van driven by Gloria Figueroa, 49, of Cloverdale, then struck debris from the crash in the roadway, Sloat said.
Figueroa's 22-year-old son Eric Figueroa told responding CHP officers Copley tried to get his mother to drive him to Ukiah, Sloat said.
Copley suffered major lacerations and a head injury. His passenger Austin Bowers, 24, of St. Helena, suffered multiple lacerations and a broken hand, Sloat said.
Copley and Bowers were taken to Santa Rosa Memorial Hospital where Copley was arrested on suspicion of DUI. The CHP determined he was driving without a license and had an outstanding warrant for a previous conviction for driving unlicensed, Sloat said.
Copley was later transferred to the UC Davis Medical Center, Sloat said.
Trettin suffered moderate injuries and also went to Santa Rosa Memorial Hospital, Sloat said.