The shooting occurred near Turk and Taylor streets at around 5:30 p.m.
Police said the suspect or suspects drove up the first block of Turk Street and shot a man multiple times. A woman was also struck by the gunfire and police believe she was not an intended target.
Both victims were taken to a hospital. The woman is in critical condition and the man is in stable condition, according to police.
Officers are searching for the suspect and suspect vehicle, which was described as a gray four-door vehicle.