Officers responded to a report of a stabbing at a gas station in the 3200 block of Delta Fair Boulevard at about 7:40 p.m., police said.
A Chevron gas station is located at 3201 Delta Fair Blvd.
The officers arrived and found a man suffering from several stab wounds, according to police.
The man, a 49-year-old Antioch resident whose name has not yet been released, was taken to a hospital where he was pronounced dead, police said.
Police made contact with a person at the scene. The person was taken to the Police Department for questioning, but no arrests have been made, according to police.
The incident remains under investigation.
Anyone with information about the stabbing is asked to call Antioch police at (925) 779-6894.