The trailer overturned at the Carlson Boulevard on-ramp to eastbound Interstate Highway 80 at about 3 a.m., according to the California Highway Patrol.
Gas leaked from the vehicle, but was contained to the roadway, CHP Officer James Evans said.
The on-and off-ramps of eastbound Highway 80 have been closed as crews work to clear the trailer and gas from the roadway, Evans said.
It is unknown when they will reopen, he said.
A nearby hotel was evacuated as a precaution, a Richmond fire dispatcher said.