Officers responded to a report of a shooting near Alemany Boulevard and southbound Interstate Highway 280 at about 11 p.m., according to San Francisco police.
San Francisco resident Clifton Chatman suffered at least one gunshot wound and was pronounced dead at the scene, police said.
A second shooting victim was taken to a hospital in serious condition.
Investigators had not determined if the shooting was gang related.
Anyone with information about the shooting is asked to call the Police Department's anonymous tip line at (415) 575-4444 or to send a tip by text message to TIP411 with "SFPD" in the message.