The fire was reported at 2:36 a.m. on East Country Club Drive, East Contra Costa County Fire Protection District Acting Chief Hugh Henderson said.
Firefighters in the first engine could see smoke and flames as they approached the home, and called for a second alarm.
When they arrived, firefighters found the first floor of the two-story home engulfed in flames. The fire was threatening two neighboring homes, Henderson said.
Thirty-three firefighters responded to the blaze and were able to quickly contain it to the home where it started, but continued to battle heavy smoke and flames for more than an hour.
The fire was declared under control at 3:51 a.m., Henderson said.
One firefighter was taken to a nearby hospital to be treated for smoke inhalation and heat exposure. He has since been released.
The fire caused an estimated $300,000 in damage to the house of origin and minor smoke and heat damage to the two neighboring homes, Henderson said.
The cause of the fire is still under investigation.
The fire district received mutual aid assistance from Contra Costa County Fire Protection District.